| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/4/2023 | Cla | Kerkering | Released | | | Before |
| 4/4/2023 | Cla | Megill,Tr | Signed | | | Before |
| 4/4/2023 | Cla | Megill,Tr | Demoted to reserve roster | | | Before |
| 4/6/2023 | Bil | Jimenez,J | Promoted to active roster | | | Before |
| 4/6/2023 | HoH | Strahm | Promoted to active roster | | | Before |
| 4/9/2023 | Bil | Baumann | Demoted to reserve roster | | | Before |
| 4/9/2023 | Cle | Joyce | Released | | | Before |
| 4/9/2023 | Cle | Kerkering | Signed | | | Before |
| 4/9/2023 | Cle | Kerkering | Demoted to reserve roster | | | Before |
| 4/9/2023 | Nor | Holderman | Promoted to active roster | | | Before |
| 4/9/2023 | Nor | Middleton | Promoted to active roster | | | Before |
| 4/9/2023 | Nor | Pfaadt | Demoted to reserve roster | | | Before |
| 4/9/2023 | Nor | Weaver | Demoted to reserve roster | | | Before |
| 4/13/2023 | Lou | Meadows,P | Promoted to active roster | | | Before |
| 4/14/2023 | Cla | Abreu,J | Demoted to reserve roster | | | Before |
| 4/14/2023 | Cla | Abreu,J | Promoted to active roster | | | Before |
| 4/14/2023 | Cla | Vientos | Promoted to active roster | | | Before |
| 4/16/2023 | Bro | Andujar | Promoted to active roster | | | Before |
| 4/16/2023 | Bro | Pruitt | Demoted to reserve roster | | | Before |
| 4/17/2023 | Sto | Alexander,T | Signed | | | Before |
| 4/17/2023 | Sto | Fujinami | Released | | | Before |
| 4/19/2023 | Cle | Villar | Promoted to active roster | | | Before |
| 4/23/2023 | Bro | Andujar | Demoted to reserve roster | | | Before |
| 4/23/2023 | Bro | Pruitt | Promoted to active roster | | | Before |
| 4/23/2023 | Cla | Gurriel,L | Traded away | Kin | | After |
| 4/23/2023 | Cla | Siri | Acquired via trade | Kin | | After |
| 4/23/2023 | HoH | Clement | Demoted to reserve roster | | | Before |
| 4/23/2023 | HoH | Martini | Promoted to active roster | | | Before |
| 4/23/2023 | Iow | Winn,M | Promoted to active roster | | | Before |
| 4/23/2023 | Kin | Gurriel,L | Acquired via trade | Cla | | After |
| 4/23/2023 | Kin | Siri | Traded away | Cla | | After |
| 4/24/2023 | Chi | Tapia,R | Promoted to active roster | | | Before |
| 4/25/2023 | Cla | Abreu,J | Promoted to active roster | | | Before |
| 4/26/2023 | Bil | Baumann | Promoted to active roster | | | Before |
| 4/26/2023 | Lou | Harris II,M | Demoted to reserve roster | | | Before |
| 4/27/2023 | Cle | Villar | Demoted to reserve roster | | | Before |
| 4/27/2023 | HoH | Davis,Jo | Promoted to active roster | | | Before |
| 4/27/2023 | HoH | Haggerty | Promoted to active roster | | | Before |
| 4/27/2023 | HoH | McKenna | Demoted to reserve roster | | | Before |
| 4/27/2023 | Lou | Harris II,M | Promoted to active roster | | | Before |
| 4/27/2023 | Lou | Meadows,P | Demoted to reserve roster | | | Before |
| 4/28/2023 | HoH | Ryu | Promoted to active roster | | | Before |
| 4/28/2023 | Kin | Blackburn | Promoted to active roster | | | Before |
| 4/28/2023 | Kin | Gonsolin | Demoted to reserve roster | | | Before |
| 5/1/2023 | Chi | Means | Promoted to active roster | | | Before |
| 5/1/2023 | Sto | Basabe | Released | | | Before |
| 5/1/2023 | Sto | Maton,N | Signed | | | Before |
| 5/1/2023 | Sto | Renfroe | Released | | | Before |
| 5/1/2023 | Sto | Rortvedt | Signed | | | Before |
| 5/2/2023 | Bil | Gonzales,N | Promoted to active roster | | | Before |
| 5/3/2023 | The | Suarez,Ro | Promoted to active roster | | | Before |
| 5/4/2023 | Bro | Andujar | Promoted to active roster | | | Before |
| 5/4/2023 | Bro | Pruitt | Demoted to reserve roster | | | Before |
| 5/5/2023 | HoH | Cobb | Demoted to reserve roster | | | Before |
| 5/5/2023 | Iow | Sheets | Signed | | | Before |
| 5/5/2023 | Iow | Shuster | Released | | | Before |
| 5/7/2023 | Bil | Gausman | Demoted to reserve roster | | | Before |
| 5/7/2023 | Bil | Pena | Demoted to reserve roster | | | Before |
| 5/7/2023 | Cle | Shuster | Signed | | | Before |
| 5/7/2023 | Cle | Shuster | Demoted to reserve roster | | | Before |
| 5/7/2023 | Cle | Villar | Released | | | Before |
| 5/7/2023 | Iow | Sheets | Demoted to reserve roster | | | Before |
| 5/7/2023 | Iow | Soroka | Promoted to active roster | | | Before |
| 5/7/2023 | Phi | Maeda | Promoted to active roster | | | Before |
| 5/8/2023 | Bil | Blanco,R | Demoted to reserve roster | | | Before |
| 5/8/2023 | Bil | Gausman | Promoted to active roster | | | Before |
| 5/8/2023 | Bro | Pruitt | Promoted to active roster | | | Before |
| 5/8/2023 | Cla | Abreu,J | Released | | | Before |
| 5/8/2023 | Cla | Renfroe | Signed | | | Before |
| 5/8/2023 | HoH | Cobb | Promoted to active roster | | | Before |
| 5/8/2023 | HoH | Ryu | Demoted to reserve roster | | | Before |
| 5/9/2023 | Chi | Jimenez,E | Demoted to reserve roster | | | Before |
| 5/9/2023 | Cla | Rodgers | Demoted to reserve roster | | | Before |
| 5/9/2023 | Iow | Neto | Demoted to reserve roster | | | Before |
| 5/10/2023 | Bro | Andujar | Demoted to reserve roster | | | Before |
| 5/10/2023 | Bro | Chavez | Promoted to active roster | | | Before |
| 5/12/2023 | Iow | Sheets | Released | | | Before |
| 5/12/2023 | Iow | Vines | Signed | | | Before |
| 5/12/2023 | Iow | Vines | Demoted to reserve roster | | | Before |
| 5/14/2023 | Chi | Barria | Demoted to reserve roster | | | Before |
| 5/14/2023 | Chi | Jimenez,E | Promoted to active roster | | | Before |
| 5/18/2023 | Cle | Kelly,C | Promoted to active roster | | | Before |
| 5/18/2023 | Pen | Urias,L | Promoted to active roster | | | Before |
| 5/18/2023 | Phi | Jax | Promoted to active roster | | | Before |